Directory Calendar News Careers Alumni Giving

Kyongnyon Nam, PhD

Research instructor, Environmental and Occupational Health

Contact

Room 4120A, Public Health
R-znvy: xla0@cvgg.rqh
Primary Phone: 967-179-6675


Personal Statement

My main research goals are to establish the information of genome-wide epigenetic changes and identification of genetic marker involved in diseases for improved diagnosis. During my Ph.D. program, I was involved in numerous studies and publications related to antioxidant, anti-inflammatory, memory enhancement, and neuroprotective activity from primarily natural resources. My Ph.D. research has enhanced my understanding of molecular and cellular biology and has given me additional experience and technical training in various in vivo and in vitro experiments. Moreover, it provided me with working knowledge in immunology and pharmacology. Since I have joined my current group, I have developed a strong interest in epigenetics, molecular epidemiology, transcriptional modification, and its implications for Alzheimer’s disease. I gained the extensive expertise for my interest in areas such as chromatin immunoprecipitation (ChIP), ChIP-seq, RNA-seq and computational analysis. I have generated genome wide transcriptional and epigenetic profiling in response to various risk factors from different cell types and Alzheimer's disease mice models. The proposed research builds on our preliminary research and will provide understanding the development of Alzheimer’s disease in response to various risk factors and potential therapeutic strategies.


Education

2010 | KyungHee University, Republic of Korea | Doctor of Philosophy in Medical Science

2006 | KyungHee University, Republic of Korea | Master of Medical Science


Selected Publications

  1. Nam KN, Wolfe CM, Fitz NF, Letronne F, Castranio EL, Mounier A, Schug J, Lefterov I, Koldamova R., Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice., Biochim Biophys Acta. 2018 Jan;1864(1):152-161. doi: 10.1016/j.bbadis.2017.10.018. Epub 2017 Oct 14.
  2. Nam KN, Mounier A, Wolfe CM, Fitz NF, Carter AY, Castranio EL, Kamboh HI, Reeves VL, Wang J, Han X, Schug J, Lefterov I, Koldamova R., Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice., Sci Rep. 2017 Jun 27;7(1):4307. doi: 10.1038/s41598-017-04412-2.
  3. Castranio EL, Mounier A, Wolfe CM, Nam KN, Fitz NF, Letronne F, Schug J, Koldamova R, Lefterov I., Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury., Neurobiol Dis. 2017 Sep;105:1-14. doi:
    10.1016/j.nbd.2017.05.006. Epub 2017 May 11.
  4. Carter AY, Letronne F, Fitz NF, Mounier A, Wolfe CM, Nam KN, Reeves VL, Kamboh H, Lefterov I, Koldamova R., Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice., PLoS One. 2017 Feb 27;12(2):e0172161. doi: 10.1371/journal.pone.0172161.
  5. Nam KN, Mounier A, Fitz NF, Wolfe CM, Schug J, Lefterov I, Koldamova R., RXR controlled regulatory networks identified in mouse brain counteract deleterious effect of Aβ oligomers., Sci Rep., 2016 Apr 7;6:24048. doi: 10.1038/srep24048.
  6. Mounier A, Georgiev D, Nam KN, Fitz NF, Castranio EL, Wolfe CM, Cronican AA, Schug J, Lefterov I, Koldamova R., Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity., J Neurosci., 2015 Aug 26;35(34):11862-76. DOI: 10.1523/JNEUROSCI.1001-15.2015.  
  7. Lefterov I, Schug J, Mounier A, Nam KN, Fitz NF, Koldamova R., RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment., Neurobiol Dis., 2015 Oct;82:132-40. DOI: 10.1016/j.nbd.2015.05.019




Kyongnyon  Nam
© 2018 by University of Pittsburgh Graduate School of Public Health

Login  |  Sitemap