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Kiflai Bein, PhD

Assistant Professor, Environmental and Occupational Health

Contact

100 Technology Dr #562, Pittsburgh, PA 15219
R-znvy: xorva@cvgg.rqh
Primary Phone: 967-179-4711
Web site:


Personal Statement

CURRENT RESEARCH AREA

Molecular basis of chemical-induced acute lung injury – The etiology of acute lung injury is complex and can be induced by numerous causes such as sepsis, trauma, pneumonia, and inhaled chemicals.  Using a mouse exposure model and tissue culture, we are investigating mechanisms critical to acrolein-induced acute lung injury.  


Education

EDUCATION
1980 / Asmera University, Asmera, Eritrea / BS / Biology/Chemistry
1983 / Addis Abeba University, Addis Abeba, Ethiopia / MS / Immunology/Biology
1991 / Wayne State University, Detroit, MI, USA / PhD / Biochemistry/Immunology


Teaching

COURSES TAUGHT

2015 / Molecular Fundamentals / EOH Course #3210 / Mentor
2012 / Molecular Fundamentals / EOH Course #3210 / Mentor
2010 / Molecular Fudamentals / EOH Course #3210 / Mentor
1989 / Biochemistry Case Study Problem Solving Sessions (Year I Medical Students) / Tutorial coordinator
1986-88 / Immunology/Microbiology Laboratory Sessions (Year I Medical Students) / Laboratory Instructor
1981-83 / Year I Biology Laboratory Sessions; Year IV Parasitoloty Laboratory Sessions / Laboratory Instructor
1983 / Year IV The Biology of the Malarial Parasite / Lecturer
1984-85 / Year IV Parasitology; Year II Invertebrate Zoology / Lecturer
1983-84 / Year I Principles of Biology; Year IV Mammalian Physiology / Lecturer
1980-81 / Year I & II Biology Laboratory Sessions / Laboratory Instructor


Selected Publications

SELECTED PUBLICATIONS - 

Bein K, Wesselkamper SC, Liu X, Dietsch M, Majumder N, Concel VJ, Medvedovic M, Sartor MA, Henning LN, Venditto C, Borchers MT, Barchowsky A, Weaver TE, Tichelaar JW, Prows DR, Korfhagen TR, Hardie WD, Bachurski CJ, Leikauf GD. Surfactant associated protein B is
critical to survival in nickel-induced injury in mice. Am J Respir Cell Mol Biol. 2009; 41(2):226-36 PMID: 19131640

Ganguly K, Depner M, Fattman C, Bein K, Oury TD, Wesselkamper SC, Borchers MT, Schreiber M, Gao F, von Mutius E, Kabesch M, Leikauf GD, Schulz H.  Superoxide dismutase 3, extracellular (SOD3) variants and lung function. Physiol Genomics 2009; 37(3): 260-7 PMID: 19318538

Stark JM, Barmada MM, Winterberg AV, Majumber N, Gibbons WJ Jr, Stark MA, Sartor MA, Medvedovic M, Kolls J, Bein K, Mailaparambil B, Krueger M, Heinzmann A, Leikauf GD, Prows DR.  Genomewide
association analysis of respiratory syncytial virus infection in mice. J Virol. 2010 Mar;84(5):2257-69. Epub 2009 Dec 16.  PMID:20015999

 Jang AS, Concel VJ, Bein K, Brant KA, Liu S, Pope-Varsalona H, Dopico Jr RA, Di YP, Knoell DL, Barchowsky A, Leikauf GD.  Endothelial Dysfunction And Claudin 5 Regulation During Acrolein-induced Lung Injury. Am J Respir Cell Mol Biol. 2011 Apr;44(4):483-90. Epub 2010 Jun 4. PMID: 20525806

 Leikauf GD, Pope-Varsalona H, Concel VJ, Liu P, Bein K, Brant KA, Dopico RA, Di YP, Jang AS, Dietsch M, Medvedovic M, Li Q, Vuga LJ, Kaminski N, You M, Prows DR. Functional genomics of chlorine-induced acute lung injury in mice. Proc Am Thorac Soc. 2010 Jul;7(4):294-6.  PMID: 20601635

Leikauf GD, Concel VJ, Liu P, Bein K, Berndt A, Ganguly K, Jang AS, Brant KA,Dietsch M, Pope-Varsalona H, Dopico Jr RA, Di YP, Li Q, Vuga LJ, Medvedovic M,Kaminski N, You M, Prows DR. Haplotype Association Mapping of Acute Lung Injury in Mice Implicates Activin A Receptor, Type 1. Am J Respir Crit Care Med. 2011 Jun 1;183(11):1499-509. Epub 2011 Feb 4. PubMed PMID:
21297076.

Bein K, Leight H, Leikauf GD. JUN-CCAAT/Enhancer Binding Protein (C/EBP) Complexes Inhibit Surfactant Associated Protein B Promoter Activity. Am J Respir Cell Mol Biol 2011 Aug;45(2):436-44. Epub 2010 Dec 10.  PubMed PMID: 21148742.

 Fabisiak JP, Medvedovic M, Alexander DC, McDunn J, Concel VJ, Bein K, An Soo Jang AS, Annerose Berndt5 A, Louis J Vuga LJ, Kelly A Brant KA, Hannah Pope-Varsalona H, Richard A Dopico RA Jr. 1, Koustav Ganguly K, Swapna Upadhyay S, Qian Li Q, Naftali Kaminski NK, George D. Leikauf GD. Integrative metabolome and transcriptome profiling reveals discordant energetic stress between mouse strains with differential sensitivity to acrolein-induced acute lung injury. Molecular Nutrition and Food Science 2011 Sep;55(9):1423-34.  Epub 2011 Aug 8.  PMID: 21823223

 Leikauf GD, Pope-Varsalona H, Concel VJ, Liu P, Bein K, Berndt A, Martin TM, Ganguly K, Jang AS, Brant KA, Dopico RA Jr, Upadhyay S, Di YP, Li Q, Hu Z, Vuga LJ, Medvedovic M, Kaminski N, You M, Alexander DC, McDunn JE, Prows DR, Knoell DL, Fabisiak JP. Integrative assessment of chlorine-induced acute lung injury in mice. American journal of respiratory cell and molecular biology. 2012 Aug;47(2):234-44. PMID:22447970. PMCID:PMC3423464.

 Bein K, Di Giuseppe M, Mischler SE, Ortiz LA, Leikauf GD. Lipopolysaccharide-treated macrophages cytokines repress surfactant protein B in lung epithelial cells. American journal of respiratory cell and molecular biology. 2013 Aug;49(2):306-15. PMID:23590297.

 Leikauf GD, Concel VJ, Bein K, Liu P, Berndt A, Martin TM, Ganguly K, Jang AS, Brant KA, Dopico Jr RA, Upadhyay S, Cario CL, Di YP, Vuga LJ, Kostem E, Eskin E, You M, Kaminski N, Prows DR,
Knoell DL, Fabisiak JP. Functional Genomic Assessment of Phosgene-induced Acute Lung Injury in Mice. American journal of respiratory cell and molecular biology. 2013 Sep;49(3):368-83. PMID:23590305.

 Ganguly K, Martin TM, Concel VJ, Upadhyay S, Bein K, Brant KA, George L, Mitra A, Thimraj TA, Fabisiak JP, Vuga LJ, Fattman C, Kaminski N, Schulz H, and Leikauf GD.   Secreted Phosphoprotein 1 (Spp1) is a Determinant of Lung Function Development in Mice.  American journal of respiratory cell and molecular biology. 2014 May 09

Bein, K. and Leikauf, G.D. Acrolein – a pulmonary hazard. Molecular Nutrition and Food Research 2011 Sep;55(9):1342-60. PMID: 21994168

Kiflai  Bein
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