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Jian-Min Yuan, MD, PhD

Arnold Palmer Endowed Chair in Cancer Prevention, University of Pittsburgh Cancer Institute

Professor, Epidemiology

Contact

University of Pittsburgh Medical Center (Shadyside) Cancer Pavilion, 5150 Centre Avenue - Suite 4C, Room 470, Pittsburgh, PA 15232
R-znvy: lhnaw@hczp.rqh
Primary Phone: 967-319-2334
Fax: 967-319-2383

Assistant(s): 
Brooke Spencer, oqf67@cvgg.rqh,

Personal Statement

Environmental exposure and gene-environmental interaction in the etiology of cancer Biomarkers in relation to the development of cancer and risk prediction of cancer Chemopreventive effect of dietary agents for primary prevention of cancer Health outcomes and prognosis of cancer patients after behavior changes [Program Leader, Cancer Epidemiology, Prevention & Control Program]


Education

1983 | Shanghai Medical University | MD, Medicine
1986 | Shanghai Medical University | MPH, Public Health/Epidemiology
1996 | University of Southern California | PhD, Epidemiology


Research Interests

  • Environmental exposure and gene-environmental interaction in the etiology of cancer
  • Biomarkers in relation to the development of cancer and risk prediction of cancer
  • Chemopreventive effect of dietary agents for primary prevention of cancer
  • Health outcomes and prognosis of cancer patients after behavior changes


Research Support

Principal Investigator

07/01/2014-06/30/2019       
Translational Research Training in Cancer Etiology and Prevention
National Institutes of Health (NIH)/National Cancer Institute (NCI)

10/01/14-09/30/2019           
The Cancer Epidemiology Cohorts in Singapore and Shanghai      
National Institutes of Health (NIH)/National Cancer Institute (NCI)

Co-Principal Investigator (Subaward)

07/01/2012-06/30/2016
Urinary Metalloproteinases and Breast Cancer Risk in a Prospective Cohort
NIH/NCI

09/10/1997-07/31/2020
Cancer Center Support Grant
(Associate Director & Program Co-Leader) 
NIH/NCI

07/01/2013-06/30/2016
An Integrated Study of Mitochondrial Pathway in Colorectal Cancer
NIH/NCI
UMN-Sub

08/04/2011-05/30/2016
Epigenetic Changes Link COPD and Lung Cancer
NIH/NCI
Lovelace Research Institute Sub

04/10/2015-03/31/2020
Genome-Wide Association Study in HCC
NIH/NCI
MD Anderson Cancer Center Sub

05/05/2015-04/30/2018
Pancreatic Cancer
NIH/NCI


Selected Publications

  1. Bancks MP, Odegaard AO, Koh WP, Yuan J-M, Gross MD, Pereira MA. Glycated hemoglobin and incident type 2 diabetes in singaporean chinese adults: the singapore chinese health study. PLoS ONE 10:e0119884, 2015  [PMC4361607]
  2. Butler LM, Huang JY, Wang R, Lee MJ, Yang CS, Gao YT, Yuan J-M. Urinary biomarkers of catechins and risk of hepatocellular carcinoma in the Shanghai cohort study. Am J Epidemiol 181:397-405, 2015 [PMC4380019]
  3. Cheng CY, Yamashiro K, Chen LJ, Ahn J, Huang L, Huang L, Cheung CM, Miyake M, Cackett PD, Yeo IY, Laude A, Mathur R, Pang J, Sim KS, Koh AH, Chen P, Lee SY, Wong D, Chan CM, Loh BK, Sun Y, Davila S, Nakata I, Nakanishi H, Akagi-Kurashige Y, Gotoh N, Tsujikawa A, Matsuda F, Mori K, Yoneya S, Sakurada Y, Iijima H, Iida T, Honda S, Lai TY, Tam PO, Chen H, Tang S, Ding X, Wen F, Lu F, Zhang X, Shi Y, Zhao P, Zhao B, Sang J, Gong B, Dorajoo R, Yuan J-M, Koh WP, van Dam RM, Friedlander Y, Lin Y, Hibberd ML, Foo JN, Wang N, Wong CH, Tan GS, Park SJ, Bhargava M, Gopal L, Naing T, Liao J, Ong PG, Mitchell P, Zhou P, Xie X, Liang J, Mei J, Jin X, Saw SM, Ozaki M, Mizoguchi T, Kurimoto Y, Woo SJ, Chung H, Yu HG, Shin JY, Park DH, Kim IT, Chang W, Sagong M, Lee SJ, Kim HW, Lee JE, Li Y, Liu J, Teo YY, Heng CK, Lim TH, Yang SK, Song K, Vithana EN, Aung T, Bei JX, Zeng YX, Tai ES, Li XX, Yang Z, Park KH, Pang CP, Yoshimura N, Wong TY, Khor CC. New loci and coding variants confer risk for age-related macular degeneration in East Asians. Nat Commun 6:6063, 2015 [PMC4317498]
  4. Fung C, Zhou P, Joyce S, Trent K, Yuan J-M, Grandis JR, Weissfeld JL, Romkes M, Weeks DE, Egloff AM. Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma. Cancer Lett 357:549-556, 2015 [PMC 4295492].
  5. Hecht SS, Koh WP, Wang R, Chen M, Carmella SG, Murphy SE, Yuan J-M. Elevated levels of mercapturic acids of acrolein and crotonaldehyde in the urine of chinese women in singapore who regularly cook at home. PLoS ONE 10:e0120023, 2015  [PMC4373935]
  6. Leung YY, Allen JC, Jr., Noviani M, Ang LW, Wang R, Yuan J-M, Koh WP. Association between body mass index and risk of total knee replacement, the Singapore Chinese Health Study. Osteoarthritis Cartilage 23:41-47, 2015 [PMC4275403].
  7. Odegaard AO, Koh WP, Yuan J-M, Pereira MA. Beverage habits and mortality in chinese adults. J Nutr 145:595-604, 2015 [PMC4336537].
  8. Xu L, Qu YH, Chu XD, Wang R, Nelson HH, Gao YT, Yuan J-M. Urinary levels of N-nitroso compounds in relation to risk of gastric cancer: Findings from the shanghai cohort study. PLoS ONE 10:e0117326, 2015  [PMC4319940].
  9. Dostal AM, Samavat H, Bedell S, Torkelson C, Wang R, Swenson K, Le C, Wu AH, Ursin G, Yuan J-M, Kurzer MS. The safety of green tea extract supplementation in postmenopausal women at risk for breast cancer: results of the Minnesota Green Tea Trial. Food Chem Toxicol 83:26-35, 2015 [PMC4540665] .
  10. Han Y, Dorajoo R, Ke T, Ayala B, Chang X, Khor CC, van Dam RM, Yuan J-M, Koh WP, Liu J, Goh DY, Friedlander Y, Heng CK. Interaction effects between Paraoxonase 1 variants and cigarette smoking on risk of coronary heart disease in a Singaporean Chinese population. Atherosclerosis 240:40-45, 2015 [PMC4501379].
  11. Jafar TH, Jin A, Koh WP, Yuan J-M, Chow KY. Physical activity and risk of end-stage kidney disease in the Singapore Chinese Health Study. Nephrology (Carlton) 20:61-67, 2015 [PMC4495910].
  12. Koh AS, Pan A, Wang R, Odegaard AO, Pereira MA, Yuan J-M, Koh WP. The association between dietary omega-3 fatty acids and cardiovascular death:  The Singapore Chinese Health Study. Eur J Prev Cardiol 22:364-372, 2015 [PMC4501020].
  13. Rane G, Koh WP, Kanchi MM, Wang R, Yuan J-M, Wang X. Association Between Leukocyte Telomere Length and Plasma Homocysteine in a Singapore Chinese Population. Rejuvenation Res 18:203-210, 2015 [PMC4491153].
  14. Teng GG, Pan A, Yuan J-M, Koh WP. Food sources of protein and risk of incident gout in the Singapore Chinese Health Study. Arthritis Rheumatol 67:1933-42, 2015 [PubMed – indexed for MEDLINE].
  15. Dai Z, Ang LW, Yuan J-M, Koh WP. Association between change in body weight after midlife and risk of hip fracture-the Singapore Chinese Health Study. Osteoporos Int 26:1939-47, 2015 [PMC4498249].
  16. Xu L, Qu YH, Chu XD, Wang R, Nelson HH, Gao YT, Yuan JM. Urinary levels of N-nitroso compounds in relation to risk of gastric cancer: findings from the shanghai cohort study. PLoS One 10:e0117326, 2015 [PMC4319940].
  17. Bancks MP, Odegaard AO, Koh WP, Yuan JM, Gross MD, Pereira MA. Glycated hemoglobin and incident type 2 diabetes in singaporean chinese adults: the Singapore Chinese health study. PLoS One 10:e0119884, 2015 [PMC4361607].
  18. Hecht SS, Koh WP, Wang R, Chen M, Carmella SG, Murphy SE, Yuan JM. Elevated levels of mercapturic acids of acrolein and crotonaldehyde in the urine of Chinese women in Singapore who regularly cook at home. PLoS One 10:e0120023, 2015 [PMC4373935].
  19. Pan A, Teng GG, Yuan JM, Koh WP. Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study. PLoS One 10:e0141749, 2015 [PMC4624790].
  20. Leung YY, Allen JC Jr, Noviani M, Ang LW, Wang R, Yuan JM, Koh WP. Association between body mass index and risk of total knee replacement, the Singapore Chinese Health Study. Osteoarthritis Cartilage 23:41-7, 2015 [PMC4275403].
  21. Cheng CY, Yamashiro K, Chen LJ, Ahn J, Huang L, Huang L, Cheung CM, Miyake M, Cackett PD, Yeo IY, Laude A, Mathur R, Pang J, Sim KS, Koh AH, Chen P, Lee SY, Wong D, Chan CM, Loh BK, Sun Y, Davila S, Nakata I, Nakanishi H, Akagi-Kurashige Y, Gotoh N, Tsujikawa A, Matsuda F, Mori K, Yoneya S, Sakurada Y, Iijima H, Iida T, Honda S, Lai TY, Tam PO, Chen H, Tang S, Ding X, Wen F, Lu F, Zhang X, Shi Y, Zhao P, Zhao B, Sang J, Gong B, Dorajoo R, Yuan JM, Koh WP, van Dam RM, Friedlander Y, Lin Y, Hibberd ML, Foo JN, Wang N, Wong CH, Tan GS, Park SJ, Bhargava M, Gopal L, Naing T, Liao J, Ong PG, Mitchell P, Zhou P, Xie X, Liang J, Mei J, Jin X, Saw SM, Ozaki M, Mizoguchi T, Kurimoto Y, Woo SJ, Chung H, Yu HG, Shin JY, Park DH, Kim IT, Chang W, Sagong M, Lee SJ, Kim HW, Lee JE, Li Y, Liu J, Teo YY, Heng CK, Lim TH, Yang SK, Song K, Vithana EN, Aung T, Bei JX, Zeng YX, Tai ES, Li XX, Yang Z, Park KH, Pang CP, Yoshimura N, Wong TY, Khor CC. Nat Commun 6:6063, 2015 [PMC4317498].
  22. Fung C, Zhou P, Joyce S, Trent K, Yuan JM, Grandis JR, Weissfeld JL, Romkes M, Weeks DE, Egloff AM.  Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma. Cancer Lett 357:549-56, 2015 [PMC4295492].
  23. Leung YY, Ang LW, Allen JC Jr, Noviani M, Wang R, Yuan JM, Koh WP. Response to Letters to the Editors: 1. More details on the database used by the study should be provided. 2. Mediclaim Hospital Discharge System and income levels of cohort. Osteoarthritis Cartilage 23:499-500, 2015 [PubMed - indexed for MEDLINE].
  24. Odegaard AO, Koh WP, Yuan JM, Pereira MA. Beverage habits and mortality in Chinese adults. J Nutr 145:595-604, 2015 [PMC4336537].
  25. Hu N, Wang Z, Song X, Wei L, Kim BS, Freedman ND, Baek J, Burdette L, Chang J, Chung C, Dawsey SM, Ding T, Gao YT, Giffen C, Han Y, Hong M, Huang J, Kim HS, Koh WP, Liao LM, Mao YM, Qiao YL, Shu XO, Tan W, Wang C, Wu C, Wu MJ, Xiang YB, Yeager M, Yook JH, Yuan JM, Zhang P, Zhao XK, Zheng W, Song K, Wang LD, Lin D, Chanock SJ, Goldstein AM, Taylor PR, Abnet CC. Genome-wide association study of gastric adenocarcinoma in Asia: a comparison of associations between cardia and non-cardia tumours. Gut Jun 30, 2015 [PubMed - as supplied by publisher].
  26. Grill AE, Schmitt T, Gates LA, Lu D, Bandyopadhyay D, Yuan JM, Murphy SE, Peterson LA. Abundant Rodent Furan-Derived Urinary Metabolites Are Associated with Tobacco Smoke Exposure in Humans. Chem Res Toxicol 28:1508-16, 2015 [PubMed - in process]
  27. Smagula SF, Koh WP, Wang R, Yuan JM. Chronic disease and lifestyle factors associated with change in sleep duration among older adults in the Singapore Chinese Health Study. J Sleep Res Sep 28, 2015 [Epub ahead of print] [PubMed - as supplied by publisher].
  28. Samavat H, Dostal AM, Wang R, Bedell S, Emory TH, Ursin G, Torkelson CJ, Gross MD, Le CT, Yu MC, Yang CS, Yee D, Wu AH, Yuan JM, Kurzer MS. The Minnesota Green Tea Trial (MGTT), a randomized controlled trial of the efficacy of green tea extract on biomarkers of breast cancer risk: Study rationale, design, methods, and participant characteristics. Cancer Causes Control 26:1405-19, 2015 [PMC4567901].
  29. Koh WP, Dan YY, Goh GB, Jin A, Wang R, Yuan JM. Dietary fatty acids and risk of hepatocellular carcinoma in the Singapore Chinese health study. Liver Int Oct 7, 2015 [PubMed - as supplied by publisher].
  30. Kato N, Loh M, Takeuchi F, Verweij N, Wang X, Zhang W, Kelly TN, Saleheen D, Lehne B, Mateo Leach I, Drong AW, Abbott J, Wahl S, Tan ST, Scott WR, Campanella G, Chadeau-Hyam M, Afzal U, Ahluwalia TS, Bonder MJ, Chen P, Dehghan A, Edwards TL, Esko T, Go MJ, Harris SE, Hartiala J, Kasela S, Kasturiratne A, Khor CC, Kleber ME, Li H, Mok ZY, Nakatochi M, Sapari NS, Saxena R, Stewart AF, Stolk L, Tabara Y, Teh AL, Wu Y, Wu JY, Zhang Y, Aits I, Da Silva Couto Alves A, Das S, Dorajoo R, Hopewell JC, Kim YK, Koivula RW, Luan J, Lyytikäinen LP, Nguyen QN, Pereira MA, Postmus I, Raitakari OT, Bryan MS, Scott RA, Sorice R, Tragante V, Traglia M, White J, Yamamoto K, Zhang Y, Adair LS, Ahmed A, Akiyama K, Asif R, Aung T, Barroso I, Bjonnes A, Braun TR, Cai H, Chang LC, Chen CH, Cheng CY, Chong YS, Collins R, Courtney R, Davies G, Delgado G, Do LD, Doevendans PA, Gansevoort RT, Gao YT, Grammer TB, Grarup N, Grewal J, Gu D, Wander GS, Hartikainen AL, Hazen SL, He J, Heng CK, Hixson JE, Hofman A, Hsu C, Huang W, Husemoen LL, Hwang JY, Ichihara S, Igase M, Isono M, Justesen JM, Katsuya T, Kibriya MG, Kim YJ, Kishimoto M, Koh WP, Kohara K, Kumari M, Kwek K, Lee NR, Lee J, Liao J, Lieb W, Liewald DC, Matsubara T, Matsushita Y, Meitinger T, Mihailov E, Milani L, Mills R, Mononen N, Müller-Nurasyid M, Nabika T, Nakashima E, Ng HK, Nikus K, Nutile T, Ohkubo T, Ohnaka K, Parish S, Paternoster L, Peng H, Peters A, Pham ST, Pinidiyapathirage MJ, Rahman M, Rakugi H, Rolandsson O, Rozario MA, Ruggiero D, Sala CF, Sarju R, Shimokawa K, Snieder H, Sparsø T, Spiering W, Starr JM, Stott DJ, Stram DO, Sugiyama T, Szymczak S, Tang WH, Tong L, Trompet S, Turjanmaa V, Ueshima H, Uitterlinden AG, Umemura S, Vaarasmaki M, van Dam RM, van Gilst WH, van Veldhuisen DJ, Viikari JS, Waldenberger M, Wang Y, Wang A, Wilson R, Wong TY, Xiang YB, Yamaguchi S, Ye X, Young RD, Young TL, Yuan JM, Zhou X, Asselbergs FW, Ciullo M, Clarke R, Deloukas P, Franke A, Franks PW, Franks S, Friedlander Y, Gross MD, Guo Z, Hansen T, Jarvelin MR, Jørgensen T, Jukema JW, Kähönen M, Kajio H, Kivimaki M, Lee JY, Lehtimäki T, Linneberg A, Miki T, Pedersen O, Samani NJ, Sørensen TI, Takayanagi R, Toniolo D; BIOS-consortium; CARDIo GRAMplusCD; LifeLines Cohort Study; InterAct Consortium, Ahsan H, Allayee H, Chen YT, Danesh J, Deary IJ, Franco OH, Franke L, Heijman BT, Holbrook JD, Isaacs A, Kim BJ, Lin X, Liu J, März W, Metspalu A, Mohlke KL, Sanghera DK, Shu XO, van Meurs JB, Vithana E, Wickremasinghe AR, Wijmenga C, Wolffenbuttel BH, Yokota M, Zheng W, Zhu D, Vineis P, Kyrtopoulos SA, Kleinjans JC, McCarthy MI, Soong R, Gieger C, Scott J, Teo YY, He J, Elliott P, Tai ES, van der Harst P, Kooner JS, Chambers JC. Nat Gene. 47:1282-93, 2015 [PMC4719169].
  31. Weissfeld JL, Lin Y, Lin HM, Kurland BF, Wilson DO, Fuhrman CR, Pennathur A, Romkes M, Nukui T, Yuan JM, Siegfried JM, Diergaarde B. Lung Cancer Risk Prediction Using Common SNPs Located in GWAS-Identified Susceptibility Regions J Thorac Oncol 10:1538-45, 2015 [PMC4636453].
  32. Dorajoo R, Sun Y, Han Y, Ke T, Burger A, Chang X, Low HQ, Guan W, Lemaitre RN, Khor CC, Yuan JM, Koh WP, Ong CN, Tai ES, Liu J, van Dam RM, Heng CK, Friedlander Y. Genes Nutr 10:53, 2015 [PMC4653118].
  33. VoPham T, Brooks MM, Yuan JM, Talbott EO, Ruddell D, Hart JE, Chang CC, Weissfeld JL. Pesticide exposure and hepatocellular carcinoma risk: A case-control study using a geographic information system (GIS) to link SEER-Medicare and California pesticide data. Environ Res 143 (Pt A):68-82, 2015 [PMC4641787].
  34. Bassig BA, Shu XO, Koh WP, Gao YT, Purdue MP, Butler LM, Adams-Haduch J, Xiang YB, Kemp TJ, Wang R, Pinto LA, Zheng T, Ji BT, Hosgood HD, Hu W, Yang G, Zhang H, Chow WH, Kim C, Seow WJ, Zheng W, Yuan JM, Lan Q, Rothman N.  Soluble levels of CD27 and CD30 are associated with risk of non-Hodgkin lymphoma in three Chinese prospective cohorts. Int J Cancer 137:2688-95, 2015 [PubMed - indexed by MEDLINE].
  35. Wang Z, Dai J, Hu N, Miao X, Abnet CC, Yang M, Freedman ND, Chen J, Burdette L, Zhu X, Chung CC, Ren C, Dawsey SM, Wang M, Ding T, Du J, Gao YT, Zhong R, Giffen C, Pan W, Koh WP, Dai N, Liao LM, Yan C, Qiao YL, Jiang Y, Shu XO, Chen J, Wang C, Ma H, Su H, Zhang Z, Wang L, Wu C, Xiang YB, Hu Z, Yuan JM, Xie L, Zheng W, Lin D, Chanock SJ, Shi Y, Goldstein AM, Jin G, Taylor PR, Shen H. Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies. Gut Dec 23, 2015 [Epub ahead of print] [PubMed - as supplied by publisher].
  36. Teng GG, Pan A, Yuan JM, Koh WP.  Cigarette smoking and risk of incident gout in the Singapore Chinese Health Study. Arthritis Care Res (Hoboken). Dec 29, 2015 [Epub ahead of print] [PubMed - as supplied by publisher].
  37. Hu ZH, Connett JE, Yuan JM, Anderson KE. Role of survivor bias in pancreatic cancer case-control studies. Ann Epidemiol 26:50-6. [Epub ahead of print] [PubMed - in process].
  38. Sun Y, Koh WP, Yuan JM, Choi H, Su J, Ong CN, van Dam RM. Plasma α-Linolenic and Long-Chain ω-3 Fatty Acids Are Associated with a Lower Risk of Acute Myocardial Infarction in Singapore Chinese Adults. J Nutr 146:275-82, 2016 [PMC4725432].
  39. Huang JY, Butler LM, Wang R, Jin A, Koh WP, Yuan JM. Cancer Epidemiol Biomarkers Prev 25:417-24, 2016 [PMC4767683].
  40. Dai Z, Wang R, Ang LW, Yuan JM, Koh WP. Bone turnover biomarkers and risk of osteoporotic hip fracture in an Asian population. Bone 83:171-7, 2016 [PMC4724247].
  41. Akosionu O, Virnig B, Call KT, Yuan J-M, Chanthanouvong S, Nguyen RH. The Impact of Gender Differences in Attitudes and Beliefs Concerning HBV Vaccination and Screening in the Lao Community. J Immigr Minor Health 18:277-81, 2016 [PubMed - in process].
  42. Tan LC, Methawasin K, Tan EK, Tan JH, Au WL, Yuan J-M, Koh WP. Dietary cholesterol, fats and risk of Parkinson's disease in the Singapore Chinese Health Study. J Neurol Neurosurg Psychiatry 87:86-92, 2016 [PubMed – in process].

Jian-Min  Yuan
© 2017 by University of Pittsburgh Graduate School of Public Health

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