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Dr Jim (James) Peterson, , PhD

Associate Professor, Environmental and Occupational Health

Contact

552 BRIDG, 100 Technology Drive, Pittsburgh, PA 15219
R-znvy: wvzzlc@cvgg.rqh
Primary Phone: 967-179-8027
Web site:


Personal Statement

The primary objective of the work in our laboratory is to elucidate the response of metalloproteins, especially hemoglobins and mitochondrial enzyme complexes, to environmental and occupational stressors/toxicants.  We are also engaged in the search for chemical countermeasures to ameliorate the effects of the stressors/toxicants and the development of physical methods to study the sub-molecular, molecular and cellular mechanisms of intoxication and their antagonism by various antidotes.


Education

1976 | University of Essex UK | BSc (Hon) Biological Chemistry
1981 | University of Essex UK | PhD Chemistry


Teaching

Environmental Health Chemistry (EOH 2309)
Transport and Fate of Environmental Agents (EOH 2122)
Special Topics in Bio-inorganic Toxicology


Selected Publications

J. Peterson*, L.L. Pearce and E.L. Bominaar:  “Visible Region Magnetic Linear Dichroism Spectra of Ferrocytochrome c and Deoxymyoglobin:  Demonstration of a New Tool for the Study of Metalloproteins”;  J. Am. Chem. Soc, 121, 5972-5980 (1999).


L. L. Pearce, B. R. Pitt, B. R. and J. Peterson*: “The Peroxynitrite Reductase Activity of Cytochrome c Oxidase Involves a Two-Electron Redox Reaction at the Heme a3-CuB site”;  J. Biol. Chem., 274, 35763-7 (1999). 

 A.J. Kanai*, L.L. Pearce, P.R. Clemens, L.A. Birder, M.M. VanBibber, S.-Y. Choi, W.C. deGroat, J. Peterson:  “Identification of a Neuronal Nitric Oxide Synthase in Isolated Cardiac Mitochondria Using Electrochemical Detection”; Proc. Natl. Acad. Sci. USA, 98, 14126-14131 (2001).

 L.L. Pearce*, A.J. Kanai, L.A. Birder, B.R. Pitt, J. Peterson*:  “The Catabolic Fate of Nitric Oxide:  The Nitric Oxide Oxidase and Peroxynitrite Reductase Activivites of Cytochrome Oxidase”; J. Biol. Chem. 277, 13556-13562 (2002).

E.L. Bominaar*, J. Peterson*:  “Resolving Molecular Electronic Spectra Using Magnetic Linear Dichroism”; Anal. Chem. 74, 527A-533A (2002).

J. Peterson*, T.J. Collins, E. Münck, E.L. Bominaar*:  “Resolution of Overlapping Charge-transfer Transitions by a Combined Absorption-MCD-MLD Approach”; Chem. Phys. Lett., 365, 164-169 (2002).

J. Peterson*, A.J. Kanai, L.L. Pearce:  “A Mitochondrial Role for Catabolism of Nitric Oxide in Cardiomyocytes not Involving Oxymyoglobin”; Am. J. Physiol. Heart Circ. Physiol. 286, H55-H58 (2004).

L.K. Cambal, M.R. Swanson, Q. Yuan, A.C. Weitz, H.-H. Li, B.R. Pitt, L.L. Pearce and J. Peterson*: Acute, Sublethal Cyanide Poisoning in Mice Is Ameliorated by Nitrite Alone:  Complications Arising from Concomitant Administration of Nitrite and Thiosulfate as an Antidotal Combination”; Chem. Res. Tox. 24, 1104-1112 (2011).

Leah K. Cambal, Andrew C. Weitz, Hui-Hua Li, Yang Zhang, Xi Zheng, Linda L. Pearce, Jim
Peterson*: “Comparison of the relative propensities of isoamyl nitrite and sodium nitrite to ameliorate acute cyanide poisoning in mice and a novel antidotal effect arising from anesthetics”; Chem. Res. Toxicol. 26,
828-836 (2012).


Oscar S. Benz, Quan Yuan, Andrew A. Amoscato, Linda L. Pearce, Jim Peterson “Co(III)TMPyP is an Antidote for Acute Cyanide Toxicity” Chemical Research in Toxicology. (2012)25, 2687–2703.

Sang-Min Lee, Joseph N. McLaughlin, Daniel R. Frederick, Lin Zhu, Karla Wasserloos, Iris Kaminski, Octavia Peck-Palmer ,Linda Pearce,  Jim Peterson, CBI Person, Jin; Joseph D. Latoche, Tim D. Oury, Cheryl L. Fattman, Donna Beer-Stolz, John F. Alcorn, Derek C. Angus,
Bruce R. Pitt, A. Murat Kaynar   “Metallothionien-induced zinc partitioning exacerbates hyperoxic induced lung injury”, Am J Physiol Lung Cell Mol Physiol March 1, (2013) 304:L350-L360

Leah K. Cambal Andrew C. Weitz, Hui-Hua Li, Xi Zheng, Linda L. Pearce and Jim Peterson “Alternative Nitrite Therapies for Acute Cyanide Poisoning in Mice: Complications Arising from Anesthetics” Chemical Research in Toxicology. (2013) May20;26(5):828-36. PMID:23536974.

Angela Fago, Alvin L. Crumbliss, Michael P. Hendrich, Linda L. Pearce, Jim Peterson, Robert Henkens, and Celia Bonaventura “Oxygen Binding to Partially Nitrosylated Hemoglobin” Biochimica Biophysica Acta - Proteins and Proteomics Biochimica et Biophysica Acta. (2013) April 25. PMID:23624264.

Andrea A. Cronican, Kristin L.  Frawley, Humza Ahmed, Linda L. Pearce and Jim Peterson “Antagonism of Acute Sulfide Poisoning in Mice by Nitrite Anion without Methemoglobinemia” in press (2015) Chemical Research in Toxicology


Jim (James)   Peterson
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