Directory Calendar News Careers Alumni Giving

Ernesto T. A. Marques, Jr., MD, PhD

Associate Professor, Infectious Diseases and Microbiology

Public Health Researcher, FIOCRUZ

Contact

9022 BST3, 3501 Fifth Avenue, Pittsburgh, PA 15260
R-znvy: znedhrf@cvgg.rqh
Primary Phone: 967-193-7507
Secondary Phone: 998-054-8577


Personal Statement

Keywords: Vaccinology, Immunomics,  Molecular mechanisms of dengue immunity and pathogenicity

Research Summary. The research interest of Dr. Marques is designing novel vaccine strategies, immunotherapies, diagnostic markers and disease surveillance tools based on  human samples from well characterized cohorts. The strategy he uses is based on the development of detailed T and B cell epitopes maps and the characterization of innate immune response induced by the pathogenic agents. The laboratory apply a combination of computational technologies, high throughput immune assays in human samples. Using this information we explore patterns correlated either with immunity or pathogenicity and design novel antigen formulations containing selected epitopes, adjuvants and adequate delivery methods. Currently we are applying this strategy to study Zika, Dengue, yellow fever, HIV among other agents.  Dr, Marques is also the inventor of several vaccine and diagnostic technologies.  Some of his technologies are currently licensed by leading pharmaceutical companies.


Education

1993 | Federal University of Pernambuco, Recife, Brazil | Medical Doctor - MD
1999 | The Johns Hopkins University School of Medicine  | Doctor of Philosophy - PhD


Teaching

IDM - 2003 - Host Response to Microbial Infection - Course Coordinator
IDM - 2010 - Biology of Pathogens - Lecturer
IDM - 2014 - Functional Genomics of Microbial Pathogens - Lecturer
IDM - 2038 - Prevention, Treatment, and Control of Global Infectious Diseases- Lecturer


Selected Publications

Marques ETA, Burke DS.  (2017). Tradition and innovation in development of a Zika vaccine. Lancet.  

Magalhaes T, Braga C, Cordeiro MT, Oliveira ALS, Castanha PMS, Maciel APR, Amancio NML, Gouveia PN, Peixoto-da-Silva VJ Jr, Peixoto TFL, Britto H, Lima PV, Lima ARS, Rosenberger KD, Jaenisch T, Marques ETA.  (2017). Zika virus displacement by a chikungunya outbreak in Recife, Brazil.  PLoS Negl Trop Dis 11(11):e0006055.  
 
Bosch I, de Puig H, Hiley M, Carré-Camps M, Perdomo-Celis F, Narváez CF, Salgado DM, Senthoor D, O'Grady M, Phillips E, Durbin A, Fandos D, Miyazaki H, Yen CW, Gélvez-Ramírez M, Warke RV, Ribeiro LS, Teixeira MM, Almeida RP, Muñóz-Medina JE, Ludert JE, Nogueira ML, Colombo TE, Terzian ACB, Bozza PT, Calheiros AS, Vieira YR, Barbosa-Lima G, Vizzoni A, Cerbino-Neto J, Bozza FA, Souza TML, Trugilho MRO, de Filippis AMB, de Sequeira PC, Marques ETA, Magalhaes T, Díaz FJ, Restrepo BN, Marín K, Mattar S, Olson D, Asturias EJ, Lucera M, Singla M, Medigeshi GR, de Bosch N, Tam J, Gómez-Márquez J, Clavet C, Villar L, Hamad-Schifferli K, Gehrke L.  (2017). Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum.  Sci Transl Med  9. pii: eaan1589. doi: 10.1126/scitranslmed.aan1589.
 
Castanha PMS, Nascimento EJM, Braga C, Cordeiro MT, de Carvalho OV, de Mendonça LR, Azevedo EAN, França RFO, Dhalia R, Marques ETA.  (2017). Enhancement of Zika Infection by Dengue-Specific Antibodies Does Not Alter the Production of Interleukin 6 in FcγRII-Expressing K562 Cells. J Infect Dis 216:614-615.

Castanha PMS, Montarroyos UR, Silveira SMM, Albuquerque GDM, Mello MJG, Lopes KGS, Cordeiro MT, Marques ETA, Martelli CMT, Braga C.  (2017). Incidence and risk factors for Dengue virus (DENV) infection in the first 2 years of life in a Brazilian prospective birth cohort. Epidemiol Infect 145:2971-2979.

Castanha PMS, Nascimento EJM, Braga C, Cordeiro MT, de Carvalho OV, de Mendonça LR, Azevedo EAN, França RFO, Dhalia R, Marques ETA.  (2017). Dengue Virus-Specific Antibodies Enhance Brazilian Zika Virus Infection. J Infect Dis  215:781-785.

 

Palma ML, Duangkhae P, Douradinha B, Viana IFT, Rigato PO, Dhalia R, Mailliard RB, Barratt-Boyes SM, Nascimento EJM, Oshiro TM, da Silva Duarte AJ, Marques ETA.  (2017). Development of potent class II transactivator gene delivery systems capable of inducing de novo MHC II expression in human cells, in vitro and ex vivo. Gene Ther  24:342-352.

 

Faria NR, Quick J, Claro IM, Thézé J, de Jesus JG, Giovanetti M, Kraemer MUG, Hill SC, Black A, da Costa AC, Franco LC, Silva SP, Wu CH, Raghwani J, Cauchemez S, du Plessis L, Verotti MP, de Oliveira WK, Carmo EH, Coelho GE, Santelli ACFS, Vinhal LC, Henriques CM, Simpson JT, Loose M, Andersen KG, Grubaugh ND, Somasekar S, Chiu CY, Muñoz-Medina JE, Gonzalez-Bonilla CR, Arias CF, Lewis-Ximenez LL, Baylis SA, Chieppe AO, Aguiar SF, Fernandes CA, Lemos PS, Nascimento BLS, Monteiro HAO, Siqueira IC, de Queiroz MG, de Souza TR, Bezerra JF, Lemos MR, Pereira GF, Loudal D, Moura LC, Dhalia R, França RF, Magalhães T, Marques ET Jr, Jaenisch T, Wallau GL, de Lima MC, Nascimento V, de Cerqueira EM, de Lima MM, Mascarenhas DL, Neto JPM, Levin AS, Tozetto-Mendoza TR, Fonseca SN, Mendes-Correa MC, Milagres FP, Segurado A, Holmes EC, Rambaut A, Bedford T, Nunes MRT, Sabino EC, Alcantara LCJ, Loman NJ, Pybus OG. (2017). Establishment and cryptic transmission of Zika virus in Brazil and the Americas.  Nature  546:406-410.

 

Jaenisch T, Rosenberger KD, Brito C, Brady O, Brasil P, Marques ET.  (2017).  Risk of microcephaly after Zika virus infection in Brazil, 2015 to 2016. Bull World Health Organ 95:191-198.

 

Adibi JJ, Marques ET, Cartus A, Beigi RH. (2016). Teratogenic effects of the Zika virus and the role of the placenta. Lancet  387:1587-90.

Castanha PM, Braga C, Cordeiro MT, Souza AI, Silva CD, Martelli CT, van Panhuis WG, Nascimento EJ, Marques ET.   (2016). Placental transfer of dengue-specific antibodies and kinetics of dengue infection enhancing-activity in Brazilian infants. J Infect Dis   doi: 10.1093/infdis/jiw143.

Cordeiro MT, Pena LJ, Brito CA, Gil LH, Marques ET. (2016). Positive IgM for Zika virus in the cerebrospinal fluid of 30 neonates with microcephaly in Brazil.  Lancet  doi: 10.1016/S0140-6736(16)30253-7.

Hazin AN, Poretti A, Cruz DD, Tenorio M, van der Linden A, Pena LJ, Brito C, Gil LH, Miranda-Filho DB, Marques ET, Martelli CM, Alves JG, Huisman TA, Group MER.  (2016). Computed Tomographic Findings in Microcephaly Associated with Zika Virus. N Engl J Med doi: 10.1056/NEJMc1603617.

Cordeiro MT, Brito CA, Pena LJ, Castanha PM, Gil LH, Lopes KG, Dhalia R, Meneses JA, Ishigami AC, Mello LM, Alencar LX, Guarines KM, Rodrigues LC, Marques ET.  (2016). Results of a Zika Virus (ZIKV) Immunoglobulin M-Specific Diagnostic Assay Are Highly Correlated With Detection of Neutralizing Anti-ZIKV Antibodies in Neonates With Congenital Disease. J Infect Dis 214:1897-1904.

Araujo TVB, Rodrigues LC, Ximenes RA, Miranda-Filho DB, Montarroyos UR, Melo APL, Valongueiro S, Militao de Albuquerque, MDP, Souza WV, Braga C, Filho SPB, Vazquez E, Cruz DC, Bezerra LA, Henriques CMP, Castanha PM, Cordeiro MT, Dhalia R, Marques-Junior ET, Martelli CMT.   (2016). Microcephaly and Zika infection: Preliminary Report of a Case- Control Study. Lancet Infect Dis 16:1356-1363. 

Miranda-Filho DeB, Martelli CM, Ximenes RA, Araujo TV, Rocha MA, Ramos RC, Dhalia R, Franca RF, Marques ET Jr, Rodrigues LC. (2016).  Initial Description of the Presumed Congenital Zika Syndrome. Am J Public Health 106:598-600.

Nascimento EJM, Hottz ED, Garcia-Bates TM, Bozza F, Marques ETA, Jr., Barratt-Boyes SM. (2014). Emerging Concepts in Dengue Pathogenesis: Interplay between Plasmablasts, Platelets, and Complement in Triggering Vasculopathy.  Crit Rev Immunol 34:227-40.

Viana IFT, Soares TA, Lima LFO, Marques ETA, Krieger MA, Dhalia R, Lins RD.  (2013). De novo design of immunoreactive conformation-specific HIV-1 epitopes based on Top7 scaffold. RSC Advances 3:11790.

 

Ernesto T. A. Marques
© 2018 by University of Pittsburgh Graduate School of Public Health

Login  |  Sitemap