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Detcho A. Stoyanovksy, PhD

Research Associate Professor, Environmental and Occupational Health

Contact

Bridgeside Point, room 321, 100 Technology Dr, Pittsburgh, PA 15219
R-znvy: qnf66@cvgg.rqh
Primary Phone: 967-838-1465
Secondary Phone: 967-838-1485
Fax: 967-179-4816
Web site:

Assistant(s): 
Lynette Clark, yipynex@cvgg.rqh, 967-179-4255

Personal Statement

My research interests are focused on the synthesis of radiation mitigators that selectively
compartmentalize in the mitochondria of non-malignant cells and the mechanisms of S-(de)nitrosation of proteins. 


Education

1986    Faculty of Chemistry, Sofia University, Sofia, Bulgaria, EU-   M.S. degree in organic and in analytical chemistry.

1991    Bulgarian Academy of Sciences, Sofia, Bulgaria, EU- Ph.D. in biochemistry.





Selected Publications

Stoyanovsky DA, Jiang J, Murphy MP, Epperly M, Zhang X, Li S, Greenberger J, Kagan V, Bayir H. (2014) Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator. ACS Med. Chem. Lett. 5, 1304-1307

Stoyanovsky, D. A., Sparvero, L. J., Amoscato, A. A., He, R. R., Watkins, S., Pitt, B. R., Bayir, H., and Kagan, V. E. (2014) Improved spatial resolution of matrix-assisted laser desorption/ionization imaging of lipids in the brain by alkylated derivatives of 2,5-dihydroxybenzoic acid, Rapid communications in mass spectrometry : RCM 28, 403-412.

Stoyanovsky, D. A., Scott, M. J., and Billiar, T. R. (2013) Glutathione and thioredoxin type 1 cooperatively denitrosate HepG2 cells-derived cytosolic S-nitrosoproteins, Org. Biomol. Chem. 11, 4433-4437.

Stoyanovsky, D. A., Maeda, A., Atkins, J. L., and Kagan, V. E. (2011) Assessments of thiyl radicals in biosystems: difficulties and new applications, Anal. Chem. 83, 6432-6438.

Sengupta, R., Billiar, T. R., Kagan, V. E., and Stoyanovsky, D. A. (2010) Nitric oxide and thioredoxin type 1 modulate the activity of caspase 8 in HepG2 cells, Biochem. Biophys. Res. Comm. 391, 1127-1130.

Sengupta, R., Billiar, T. R., and Stoyanovsky, D. A. (2009) Studies toward the analysis of S-nitrosoproteins, Org. Biomol. Chemistry 7, 232-234.

Sengupta, R., Billiar, T. R., Atkins, J. L., Kagan, V. E., and Stoyanovsky, D. A. (2009) Nitric oxide and
dihydrolipoic acid modulate the activity of caspase 3 in HepG2 cells, FEBS lett. 583, 3525-3530.

Sengupta, R., Ryter, S. W., Zuckerbraun, B. S., Tzeng, E., Billiar, T. R., and Stoyanovsky, D. A. (2007)
Thioredoxin catalyzes the denitrosation of low-molecular mass and protein S-nitrosothiols, Biochemistry 46, 8472-8483.

Stoyanovsky, D. A., Tyurina, Y. Y., Tyurin, V. A., Anand, D., Mandavia, D. N., Gius, D., Ivanova, J., Pitt, B., Billiar, T. R., and Kagan, V. E. (2005) Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols, J. Am. Chem. Soc. 127, 15815-15823.

Cheong, E., Tumbev, V., Abramson, J., Salama, G., and Stoyanovsky, D. A. (2005) Nitroxyl triggers Ca2+ release from skeletal and cardiac sarcoplasmic reticulum by oxidizing ryanodine receptors, Cell calcium 37, 87-96.

Stoyanovsky, D. A., Schor, N. F., Nylander, K. D., and Salama, G. (2004) Effects of pH on the cytotoxicity of sodium trioxodinitrate (Angeli's salt), J. Med. Chem. 47, 210-217.

Ivanova, J., Salama, G., Clancy, R. M., Schor, N. F., Nylander, K. D., and Stoyanovsky, D. A. (2003) Formation of nitroxyl and hydroxyl radical in solutions of sodium trioxodinitrate: effects of pH and cytotoxicity, J. Biol. Chem. 278, 42761-42768.

Novakov, C. P., Feierman, D., Cederbaum, A. I., and Stoyanovsky, D. A. (2001) An ESR and HPLC-EC assay for the detection of alkyl radicals, Chem. Res. Toxicol. 14, 1239-1246.

Clancy, R., Cederbaum, A. I., and Stoyanovsky, D. A. (2001) Preparation and properties of S-nitroso-L-cysteine ethyl ester, an intracellular nitrosating agent, J. Med. Chem. 44, 2035-2038.

 Stoyanovsky, D. A., Melnikov, Z., and Cederbaum, A. I. (1999) ESR and HPLC-EC analysis of the interaction of hydroxyl radical with DMSO: rapid reduction and quantification of POBN and PBN
nitroxides, Anal. Chem. 71, 715-721.

Stoyanovsky, D., Clancy, R., and Cederbaum, A. (1999) Decomposition of Sodium Trioxodinitrate (Angeli’s Salt) To Hydroxyl Radical: An ESR Spin-Trapping Study, J. Am. Chem. Soc. 121, 5093-5094.

Stoyanovsky, D. A., and Cederbaum, A. I. (1998) ESR and HPLC-EC analysis of ethanol oxidation to 1-hydroxyethyl radical: rapid reduction and quantification of POBN and PBN nitroxides, Free Rad. Biol. Med. 25, 536-545.

Stoyanovsky, D., Murphy, T., Anno, P. R., Kim, Y. M., and Salama, G. (1997) Nitric oxide activates skeletal and cardiac ryanodine receptors, Cell calcium 21, 19-29.

Stoyanovsky, D. A., Goldman, R., Jonnalagadda, S. S., Day, B. W., Claycamp, H. G., and Kagan, V. E. (1996) Detection and characterization of the electron paramagnetic resonance-silent glutathionyl-5,5-dimethyl-1-pyrroline N-oxide adduct derived from redox cycling of phenoxyl radicals in model systems and HL-60 cells, Arch. Bioch. Biophys. 330, 3-11.

Stoyanovsky, D. A., Goldman, R., Claycamp, H. G., and Kagan, V. E. (1995) Phenoxyl radical-induced thiol-dependent generation of reactive oxygen species: implications for benzene toxicity, Arch.
Biochem. Biophys. 317, 315-323.

Detcho A. Stoyanovksy
© 2017 by University of Pittsburgh Graduate School of Public Health

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