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Bedda L Rosario, PhD

Assistant Professor, Epidemiology


Epidemiology Data Center, 4420 Bayard Street, Suite 600, Pittsburgh, PA 15260
R-znvy: oye0@cvgg.rqh
Primary Phone: 967-179-5715

Personal Statement

My research interests focus on

• Application of statistical methods for the analysis of neuroimaging data

• Neuroepidemiology
• Statistical methods for the analysis of multimodality neuroimaging data
• Health sciences data

My collaborative research focuses on application of statistical methods for neuroimaging data. Examples include 

• Relationship between CT characteristics and outcome after traumatic brain injury
• Relationship between MRI markers (structural MRI, white matter hyperintensities and DTI) and mobility measures
• Relationship between neuroimaging and sleep disorders

My methodological research focuses on dimension reduction techniques and statistical methods for multimodality neuroimaging data. This includes the following topics
• Nonparametric concordance-discordance tests
• Partial Least Squares


• University of Pittsburgh – Postdoctoral Training Radiology, 2012
• University of Pittsburgh – PhD Biostatistics, 2008 
• University of Puerto Rico – MPH Biostatistics, 2002 
• University of Puerto Rico – BS Mathematics, 1995


·         Instructor, EPIDEM 2180, Epidemiological Methods 1

·         Invited Lecturer, Sample Size and Power

·         Invited Lecturer, Analysis of Brain Imaging Data

Selected Publications

Lim G, Krohner RG, Metro DG, Rosario BL, Jeong JH, Sakai T. Low-Fidelity Haptic Simulation Versus Mental Imagery Training for Epidural Anesthesia Technical Achievement in Novice Anesthesiology Residents: A Randomized Comparative Study. Anesthesia and Analgesia. 2016 May; 122 (5):1516-23. PMCID: PMC4840058. PMID: 27007077. doi: 10.1213/ANE.0000000000001260.


Wukich DK, Sambenedetto TL, Mota NM, Suder NC, Rosario BL. Correlation of SF-36 and SF-12 Component Scores in Patients With Diabetic Foot Disease. The Journal of Foot and Ankle Surgery : Official Publication of The American College of Foot and Ankle Surgeons. 2016 Mar 24. PMID: 27052155. doi: 10.1053/j.jfas.2015.12.009.


Wilckens KA, Aizenstein HJ, Nofzinger EA, James JA, Hasler BP, Rosario-Rivera BL, Franzen PL, Germain A, Hall MH, Kupfer DJ, Price JC, Siegle GJ, Buysse DJ. The role of non-rapid eye movement slow wave activity in prefrontal metabolism across young and middle-aged adults. Journal of Sleep Research. 2016 Feb 7. PMID: 26853796. doi: 10.1111/jsr.12365.


Rosario BL, Rosso AL, Aizenstein HJ, Harris T, Newman AB, Satterfield S, Studenski SA, Yaffe K, Rosano C, Health ABC Study. Cerebral White Matter and Slow Gait: Contribution of Hyperintensities and Normal-appearing Parenchyma. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2016 Jan 11. PMID: 26755683. doi: 10.1093/gerona/glv224.


Chen YJ, Rosario BL, Mowrey W, Laymon CM, Lu X, Lopez OL, Klunk WE, Lopresti BJ, Mathis CA, Price JC. PiB Relative Delivery (R1) as a Proxy of Relative Cerebral Blood Flow: Quantitative Evaluation Using Single Session 15O-Water and 11C-PiB PET. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 2015 Jun 4. PMID: 26045309. doi: 10.2967/jnumed.114.152405.


Wukich DK, Mallory BR, Suder NC, Rosario BL. Tibiotalocalcaneal Arthrodesis Using Retrograde Intramedullary Nail Fixation: Comparison of Patients With and Without Diabetes Mellitus. The Journal of Foot and Ankle Surgery : Official Publication of The American College of Foot and Ankle Surgeons. 2015 May 23. PMID: 26015305. doi: 10.1053/j.jfas.2015.02.019.


Wukich DK, Dikis JW, Monaco SJ, Strannigan K, Suder NC, Rosario BL. Topically Applied Vancomycin Powder Reduces the Rate of Surgical Site Infection in Diabetic Patients Undergoing Foot and Ankle Surgery. Foot & Ankle International. 2015 May 12. PMID: 25967254. doi: 10.1177/1071100715586567.


Raspovic KM, Hobizal KB, Rosario BL, Wukich DK. Midfoot Charcot Neuroarthropathy in Patients With Diabetes: The Impact of Foot Ulceration on Self-Reported Quality of Life. Foot & Ankle Specialist. 2015 May 8. PMID: 25956872. doi: 10.1177/1938640015585957.


Elmer J, Scutella M, Pullalarevu R, Wang B, Vaghasia N, Trzeciak S, Rosario-Rivera BL, Guyette FX, Rittenberger JC, Dezfulian C, Pittsburgh Post-Cardiac Arrest Service (PCAS). The association between hyperoxia and patient outcomes after cardiac arrest: analysis of a high-resolution database. Intensive Care Medicine. 2015 Jan; 41 (1):49-57. PMCID: PMC4337386. PMID: 25472570. doi: 10.1007/s00134-014-3555-6.


Elmer J, Wang B, Melhem S, Pullalarevu R, Pullalarevu R, Vaghasia N, Buddineni J, Rosario BL, Doshi AA, Callaway CW, Dezfulian C, University of Pittsburgh Post-Cardiac Arrest Service (PCAS). Exposure to high concentrations of inspired oxygen does not worsen lung injury after cardiac arrest. Critical Care (London, England). 2015; 19:105. PMCID: PMC4371614. PMID: 25888131. doi: 10.1186/s13054-015-0824-x.


Elmer J, Wang B, Melhem S, Pullalarevu R, Vaghasia N, Buddineni J, Rosario BL, Doshi AA, Callaway CW, Dezfulian C, University of Pittsburgh Post-Cardiac Arrest Service. Erratum to: Exposure to high concentrations of inspired oxygen does not worsen lung injury after cardiac arrest. Critical Care (London, England). 2015; 19:341. PMCID: PMC4571112. PMID: 26373827. doi: 10.1186/s13054-015-1053-z.


Wukich DK, Raspovic KM, Hobizal KB, Rosario B. Radiographic Analysis of Diabetic Midfoot Charcot Neuroarthropathy With and Without Midfoot Ulceration. Foot & Ankle International. 2014 Sep 24. PMID: 25253575. doi: 10.1177/1071100714547218.


Hasler BP, Martin CS, Wood DS, Rosario B, Clark DB. A longitudinal study of insomnia and other sleep complaints in adolescents with and without alcohol use disorders. Alcoholism, Clinical and Experimental Research. 2014 Aug; 38 (8):2225-33. PMCID: PMC4146702. PMID: 24976511. doi: 10.1111/acer.12474.


Wukich DK, Crim BE, Frykberg RG, Rosario BL. Neuropathy and poorly controlled diabetes increase the rate of surgical site infection after foot and ankle surgery. The Journal of Bone and Joint Surgery. American Volume. 2014 May 21; 96 (10):832-9. PMCID: PMC4018772. PMID: 24875024.


Woods BI, Rosario BL, Siska PA, Gruen GS, Tarkin IS, Evans AR. Determining the Efficacy of Screw and Washer Fixation as a Method for Securing Olecranon Osteotomies Utilized in the Surgical Management of Intraarticular Distal Humerus Fractures. Journal of Orthopaedic Trauma. 2014 Apr 15. PMID: 24740108.


Haney A, Buysse DJ, Rosario BL, Chen YF, Okun ML. Sleep disturbance and cardiometabolic risk factors in early pregnancy: a preliminary study. Sleep Medicine. 2014 Feb 8. PMID: 24657205.


Lee VK, Nau AC, Laymon C, Chan KC, Rosario BL, Fisher C. Successful tactile based visual sensory substitution use functions independently of visual pathway integrity. Frontiers in Human Neuroscience. 2014; 8:291. PMID: 24860473.


Woods BI, Rosario BL, Chen A, Waters JH, Donaldson W 3rd, Kang J, Lee J. The association between perioperative allogeneic transfusion volume and postoperative infection in patients following lumbar spine surgery. The Journal of Bone and Joint Surgery. American Volume. 2013 Dec 4; 95 (23):2105-10. PMID: 24306697.


Wukich DK, Hobizal KB, Raspovic KM, Rosario BL. SIRS is valid in discriminating between severe and moderate diabetic foot infections. Diabetes Care. 2013 Nov; 36 (11):3706-11. PMCID: PMC3816881. PMID: 24062324.


Wu YL, Ye Q, Eytan DF, Liu L, Rosario BL, Hitchens TK, Yeh FC, van Rooijen N, Ho C. MRI Investigation of Macrophages in Acute Cardiac Allograft Rejection after Heart Transplantation. Circulation. Cardiovascular Imaging. 2013 Oct 4. PMID: 24097421.


Acharya C, Cline RA, Jaligama D, Noel P, Delany JP, Bae K, Furlan A, Baty CJ, Karlsson JM, Rosario BL, Patel K, Mishra V, Dugampudi C, Yadav D, Navina S, Singh VP. Fibrosis reduces severity of acute-on-chronic pancreatitis in humans. Gastroenterology. 2013 Aug; 145 (2):466-75. PMCID: PMC3964816. PMID: 23684709. doi: 10.1053/j.gastro.2013.05.012.


Mathis CA, Kuller LH, Klunk WE, Snitz BE, Price JC, Weissfeld LA, Rosario BL, Lopresti BJ, Saxton JA, Aizenstein HJ, McDade EM, Kamboh MI, DeKosky ST, Lopez OL. In vivo assessment of amyloid-ß deposition in nondemented very elderly subjects. Annals of Neurology. 2013 Jun; 73 (6):751-61. PMCID: PMC3725727. PMID: 23596051. doi: 10.1002/ana.23797.


Rosario BL, Weissfeld LA, Laymon CM, Mathis CA, Klunk WE, Berginc MD, James JA, Hoge JA, Price JC. Inter-rater reliability of manual and automated region-of-interest delineation for PiB PET. NeuroImage. 2011 Apr 1; 55 (3):933-41. PMCID: PMC3057323. PMID: 21195782.


Cohen AD, Price JC, Weissfeld LA, James J, Rosario BL, Bi W, Nebes RD, Saxton JA, Snitz BE, Aizenstein HA, Wolk DA, Dekosky ST, Mathis CA, Klunk WE. Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Nov 25; 29 (47):14770-8. PMCID: PMC2810461. PMID: 19940172.


McNamee RL, Yee SH, Price JC, Klunk WE, Rosario B, Weissfeld L, Ziolko S, Berginc M, Lopresti B, Dekosky S, Mathis CA. Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurements. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2009 Mar; 50 (3):348-55. PMCID: PMC2694747. PMID: 19223409.


Rosario BL, Ziolko SK, Weissfeld LA, Price JC. Assessment of parameter settings for SPM5 spatial normalization of structural MRI data: application to type 2 diabetes. NeuroImage. 2008 Jun; 41 (2):363-70. PMCID: PMC2925520. PMID: 18394922.

Bedda L  Rosario
© 2017 by University of Pittsburgh Graduate School of Public Health

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