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Balasubramani K Goundappa, PhD

Research Assistant Professor/Senior Statistician, Epidemiology


R-znvy: onyntx@rqp.cvgg.rqh
Primary Phone: 967-193-7170
Fax: 967-179-8220

Personal Statement

I have the experience and training in the analysis of large clinical trial data particularly on Traumatic Brain injury in children a phase 3 randomized controlled trial research and as key personnel for the ongoing international trial on the Approaches and Decision in Acute Pediatric TBI (ADAPT) trial at the Epidemiology Data Center, University of Pittsburgh. I have the expertise in the area of statistical methodologies for clinical trials and am distinctively suited to the proposed study. I have the leadership skill and essential desire to effectively accomplish the work. I was involved in the development of study designs, managed and analyzed data for two federally funded national studies on the determination of effective treatment modalities for non-psychotic major depressive disorders, and mortality rates for HIV patients challenged with respiratory conditions. I have broad background knowledge in statistics, with specific training and expertise in key research areas of major depression
disorder, traumatic brain injury and HIV and pulmonary complications. I have work together with several investigators on the study design, contributes to protocol development and analysis of clinical trials in a number of different medical disciplines including major depression disorder, pulmonary infection with HIV, medical condition associated with endotracheal intubation and
traumatic brain injury. As a key personnel or co-investigator on several NIH funded grants, I have developed efficient research methodologies for several epidemiological studies of major significance for public health. I have coauthored several peer-reviewed publications from each project.


1995 | University of Western Ontario, Canada | Post-Doctoral Training in Actuarial Statistics
1992 | University of Madras, India | Doctor of Philosophy, Statistics
1987 | University of Madras, India | Masters of Philosophy
1986 | University of Madras, India | Masters of Science, Statistics
1984 | Presidency College, India | Bachelor's of Science, Statistics


My clinical trial research focused on statistical and epidemiological investigations of clinical
trial data from large multicenter clinical trials. My current research are in development and application of statistical methodologies are on, (i) Genomic Research in Alpha 1 anti-trypsin (A1AT) deficiency and Sarcoidosis, (ii) Approaches and decisions for acute pediatric traumatic brain injury trial
and (iii) Study on the vaccine effectiveness of Influenza and other respiratory virus infections in outpatients with medically attended acute respiratory infection, US Flu Network study.


1. Role: EDC Principal Investigator

Title: Flu vaccine effectiveness in those hospitalized in large diverse health system.

Funding Agency: CDC. Period: July 1, 2015 – August, 2020.  

2.  Role: Principal Investigator-Data Coordinating Center

Title: Influenza Vaccine Effectiveness for Preventing Medically Attended Laboratory-Confirmed Influenza in the United States 

Funding Agency: CDC Period: 08/01/2016-07/31/2021 

3. Role: Principal Investigator-Data Coordinating Center

Title: Enhanced Surveillance for New Vaccine Preventable Disease – The New Vaccine Surveillance Network (NVSN)

Funding Agency: CDC : Period: 09/30/2016- 08/31/2021                                            

4.   Role: PI

Title:Glaucoma Management in the African-Derived Developing World Using Laser Trabeculoplasty
Contracting Firm: West Virginia University Research Corporation
Funding Agency: NIH- R01 EY023620
Period: September 01, 2015- August 31, 2020


Selected Publications

Ling DC, Vargo JA, Balasubramani GK, Beriwal S. Underutilization of radiation therapy in early-stage marginal zone lymphoma negatively impacts overall survival. Pract Radiat Oncol. 2015 Dec 3.
[Epub ahead of print] PMID: 26852172.

Glaser SM, Mandish SF, Gill BS, Balasubramani GK, Clump DA, Beriwal S. Anaplastic thyroid cancer: Prognostic factors, patterns of care, and overall survival. Head Neck. 2016 Feb 19. doi: 10.1002/hed.24384. [Epub ahead of print] PMID: 26894506.

Ghareeb ER, Dulmage BO, Vargo JA, Balasubramani GK, Beriwal S. Underutilization of Mohs Micrographic Surgery for Less Common Cutaneous Malignancies in the United States. Dermatologic Surgery. 2016 Apr 6. [Epub ahead of print] PMID:27054447.

Horne ZD, Glaser SM, Vargo JA, Ferris RL, Balasubramani
GK, Clump DA, Heron DE, Beriwal S. Confirmation of proposed
human papillomavirus risk-adapted staging according to AJCC/UICC TNM criteria for positive oropharyngeal carcinomas. Cancer.
2016 Apr 25. doi: 10.1002/cncr.30021. [Epub ahead of print] PMID: 27111669.

Glaser SM, Vargo JA, Balasubramani GK, Beriwal S. Stage II
Testicular Seminoma: Patterns of Care and Survival by Treatment Strategy. Clin Oncol (R Coll Radiol). 2016 Mar 13. pii: S0936-6555(16)00085-6. doi: 10.1016/j.clon.2016.02.008. PMID: 27146264.

Hwang YG, Balasubramani GK, Metes ID, Levesque MC, Bridges SL Jr, Moreland LW. Differential response of serum amyloid A to different therapies in early rheumatoid arthritis and its potential value as a disease activity biomarker. Arthritis Res Ther. 2016 May 17;18(1):108. doi: 10.1186/s13075-016-1009-y. PMID:27188329.

Karen M. Xu, Beant S. Gill, Balasubramani GK, Paniti Sukumvanich, Joseph L. Kelley, Sushil Beriwal: Utilization and Role of Adjuvant Radiotherapy and Chemotherapy for Uterine Clear Cell Carcinoma A National Cancer Data Base Analysis. International Journal of Gynecological Cancer, 2016 Jan 28. [Epub ahead of print]. PMID: 2682583

Glaser SM, Vargo JA, Balasubramani GK, Beriwal S. Surveillance and Radiation Therapy for Stage I

Seminoma-Have We Learned From the Evidence? Int J Radiat Oncol Biol Phys. 2016 Jan 1;94(1):75-84. PMID:26700704

Ling DC, Vargo JA, Balasubramani GK, Beriwal S. Underutilization of radiation therapy in early-stage marginal zone lymphoma negatively impacts overall survival. Pract Radiat Oncol. 2015 Dec 3. [Epub ahead of print] PMID: 26852172

Shein SL, Ferguson NM, Kochanek PM, Bayir H, Clark RS, Fink EL, Tyler-Kabara EC, Wisniewski SR, Tian Y, Balasubramani GK, Bell MJ.  Effectiveness of Pharmacological Therapies for Intracranial Hypertension in Children With Severe Traumatic Brain Injury-Results From an Automated Data Collection System Time-Synched to Drug Administration. Pediatr Crit Care Med. 2015 Dec 15. PMID: 26673840

Amity CL, Schlenk EA, Gold KN, Eckels MM, Mohan N, Balasubramani GK, Wisniewski SR, Levesque MC, Starz TW. Agreement of Physicians and Nurses Performing Tender and Swollen Joint Counts in Rheumatoid Arthritis. J Clin Rheumatol. 2016 Jan;22(1):30-34. PMID: 26513306

Gill BS, Vargo JA, Pai SS, Balasubramani GK, Beriwal S: Management Trends and Outcomes for Stage I to II Mantle Cell Lymphoma Using the National Cancer Data Base: Ascertaining the Ideal Treatment Paradigm. Int J Radiat Oncol Biol Phys. 2015 Nov 1;93(3):668-76. PMID: 26461009.

Vargo JA, Gill BS, Balasubramani GK, Beriwal S: Treatment Selection and Survival Outcomes in Early-Stage Diffuse Large B-Cell Lymphoma: Do We Still Need Consolidative Radiotherapy?
J Clin Oncol. 2015 Aug 10. PMID: 26261253.

Vargo JA, Gill BS, Balasubramani GK, Beriwal S: What is the optimal management of early-stage low-grade follicular lymphoma in the modern era? Cancer, 2015, June 4. PMID:26042364.

Nowalk MP, Balasubramani GK, Schaffer M, Lieberman RH, Middleton DB, Eng HF, Wisniewski SR, Zimmeramn RK. Intention to receive an influenza vaccine following an acute respiratory
influenza like illness. American Journal of Health Behavior. 2015; 39(4):573-581. PMID: 26018106.

Gill BS, Bernard ME, Lin JF, Balasubramani GK, Rajagopalan MS, Sukumvanich P, Krivak TC, Olawaiye AB, Kelley JL, Beriwal S: Impact of adjuvant chemotherapy with radiation for node-positive vulvar cancer: A National Cancer Data Base (NCDB) analysis. Gynecologic Oncology. 2015; 137(3): 365-372. PMID: 25868965

Zimmerman RK, Rinaldo CR, Nowalk MP, Balasubramani GK, Moehling KK, Bullotta A, Eng HF, Raviotta JM, Sax TM, Wisniewski S. Viral infections in outpatients with medically attended acute respiratory illness during the 2012-2013 influenza season. BMC Infectious Diseases. 2015; 15(1):87. PMID: 25887948.

Chin KH, Bell MJ, Wisniewski SR, Balasubramani GK, Kochanek PM, Beers SR, Brown SD, Adelson PD; for the Paediatric Traumatic Brain Injury Consortium: Hypothermia Investigators. Effect of administration of neuromuscular blocking agents in Children with severe Traumatic brain injury on acute complication rates and outcomes: A secondary analysis from a randomized, controlled trial of therapeutic hypothermia. Pediatric Critical Care Medicine. 2015 Jan 16; PMID:25599147.

Simonetti JA, Gingo MR, Kingsley L, Kessinger C, Lucht L, Balasubramani GK, Leader JK, Huang L, Greenblatt RM, Dermand J, Kleerup EC, Morris A. Pulmonary function in HIV-infected recreational drug users in the era of anti-retroviral therapy. Journal of AIDS Clinical Research. 2014 Nov.; 5(11). PMID:25664201.

Zimmerman RK, Rinaldo CR, Nowalk MP, Balasubramani GK, Thompson MG, Moehling KK, Bullotta A, Wisniewski S. Influenza and other respiratory virus infections in outpatients with medically attended acute respiratory infection during the 2011-12 influenza season. Influenza and Other Respiratory Viruses. 2014 May 23. PMID:24852890.

Dennehy EB, Marangell LB, Martinez J, Balasubramani GK, Wisniewski SR. Clinical and Functional Outcomes of Patients Who Experience Partial Response to Citalopram: Secondary Analysis of STAR*D. Journal of Psychiatric Practice. 2014 May;20(3):178-87. PMID:24847991.

Gingo MR, Balasubramani GK, Rice TB, Kingsley L, Kleerup EC, Detels R, Seaberg EC, Greenblatt RM, Holman S, Huang L, Sutton SH, Bertolet M, Morris A. Pulmonary symptoms and diagnoses are associated with HIV in the MACS and WIHS cohorts. BMC Pulmonary Medicine. 2014;14(1):75. PMID:24884738. PMCID:PMC4021087.

Trivedi MH, Morris DW, Wisniewski SR, Lesser I, Nierenberg AA, Daly E, Kurian BT, Gaynes BN, Balasubramani GK, Rush AJ. Increase in work productivity of depressed individuals with improvement in depressive symptom severity. The American Journal of Psychiatry. 2013 Jun 1;170(6):633-41. PMID:23558394.

Adelson PD, Wisniewski SR, Beca J, Brown SD, Bell M, Muizelaar JP, Okada P, Beers SR, Balasubramani GK, Hirtz D, Paediatric Traumatic Brain Injury Consortium. Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial. Lancet Neurology. 2013 Jun;12(6):546-53. PMID:23664370.

Sung SC, Wisniewski SR, Balasubramani GK, Zisook S, Kurian B, Warden D, Trivedi MH, Rush AJ, CO-MED Study Team. Does early-onset chronic or recurrent major depression impact outcomes with antidepressant medications? A CO-MED trial report. Psychological Medicine. 2013 May;43(5):945-60. PMID:23228340.

Dording CM, LaRocca RA, Hails KA, Vitolo OV, Wisniewski SR, Balasubramani GK, Trivedi M, Fava M, Mischoulon D. The effect of sildenafil on quality of life. Annals of Clinical Psychiatry : Official Journal of The American Academy of Clinical Psychiatrists. 2013 Feb;25(1):3-10. PMID:23376864.

Gingo MR, Balasubramani GK, Kingsley L, Rinaldo CR Jr, Alden CB, Detels R, Greenblatt RM, Hessol NA, Holman S, Huang L, Kleerup EC, Phair J, Sutton SH, Seaberg EC, Margolick JB, Wisniewski SR, Morris A. The impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts. PloS One. 2013;8(3):e58812. PMID:23554932. PMCID:PMC3595204.

Farabaugh A, Alpert J, Wisniewski SR, Otto MW, Fava M, Baer L, Perlis R, Friedman E, Nyer M, Bitran S, Balasubramani GK, Inamori A, Trivedi M, Thase ME. Cognitive therapy for anxious depression in STAR(*) D: what have we learned? Journal of Affective Disorders. 2012 Dec 15;142(1-3):213-8. PMID:22877961. PMCID:PMC3483355.

Chan HN, Rush AJ, Nierenberg AA, Trivedi M, Wisniewski SR, Balasubramani GK, Friedman ES, Gaynes BN, Davis L, Morris D, Fava M. Correlates and outcomes of depressed out-patients with greater and fewer anxious symptoms: a CO-MED report. The International Journal of Neuropsychopharmacology / Official Scientific Journal of The Collegium Internationale Neuropsychopharmacologicum (CINP). 2012 Nov;15(10):1387-99. PMID:22129562.

Rush AJ, Wisniewski SR, Zisook S, Fava M, Sung SC, Haley CL, Chan HN, Gilmer WS, Warden D, Nierenberg AA, Balasubramani GK, Gaynes BN, Trivedi MH, Hollon SD. Is prior course of illness relevant to acute or longer-term outcomes in depressed out-patients? A STAR*D report. Psychological Medicine. 2012 Jun;42(6):1131-49. PMID:22008447.

Davis LL, Pilkinton P, Wisniewski SR, Trivedi MH, Gaynes BN, Howland RH, Zisook S, Balasubramani GK, Fava M, Rush AJ. Effect of concurrent substance use disorder on the effectiveness of single and combination antidepressant medications for the treatment of major depression: an exploratory analysis of a single-blind randomized trial. Depression and Anxiety. 2012 Feb;29(2):111-22. PMID:22495941. PMCID:PMC3325509.

Wang HE, Balasubramani GK, Cook LJ, Yealy DM, Lave JR. Medical conditions associated with out-of-hospital endotracheal intubation. Prehospital Emergency Care : Official Journal of The National Association of EMS Physicians and The National Association of State EMS Directors. 2011 15(3):338-46. PMID:21612386. PMCID:PMC3103090.

Balasubramani M, Schreiber EM, Candiello J, Balasubramani GK, Kurtz J, Halfter W. Molecular interactions in the retinal basement membrane system: a proteomic approach. Matrix Biology : Journal of The International Society For Matrix Biology. 2010 Jul;29(6):471-83. PMID:20403434.

Bryan C, Songer T, Brooks MM, Rush AJ, Thase ME, Gaynes B, Balasubramani GK, Trivedi MH, Fava M, Wisniewski SR. The impact of diabetes on depression treatment outcomes. General Hospital Psychiatry.  2010: 32(1):33-41. PMID:20114126.

Wang HE, Balasubramani GK, Cook LJ, Lave JR, Yealy DM. Out-of-hospital endotracheal intubation experience and patient outcomes. Annals of Emergency Medicine. 2010 Jun;55(6):527-537.e6. PMID:20138400. PMCID:PMC3071147.

Davis LL, Wisniewski SR, Howland RH, Trivedi MH, Husain MM, Fava M, McGrath PJ, Balasubramani GK, Warden D, Rush AJ. Does comorbid substance use disorder impair recovery from major depression with SSRI treatment? An analysis of the STAR*D level one treatment outcomes. Drug and Alcohol Dependence. 2010 Mar 1;107(2-3):161-70. PMID:19945804.

Shelton RC, Hollon SD, Wisniewski SR, Alpert JE, Balasubramani GK, Friedman ES, Rush AJ, Trivedi MH, Preskorn SH. Factors associated with concomitant psychotropic drug use in the treatment of major depression: a STAR*D Report. CNS Spectrums. 2009 Sep;14(9):487-98. PMID:19890231.

Bryan C, Songer T, Brooks MM, Thase ME, Gaynes B, Klinkman M, Balasubramani GK, Rush AJ, Trivedi MH, Fava M, Wisniewski SR. Do depressed patients with diabetes experience more side effects when treated with CitalopramThan their counterparts without diabetes? a STAR*D study. Primary Care Companion To The Journal of Clinical Psychiatry. 2009;11(5):186-96. PMID:19956455. PMCID:PMC2781029.

Warden D, Trivedi MH, Wisniewski SR, Lesser IM, Mitchell J, Balasubramani GK, Fava M, Shores-Wilson K, Stegman D, Rush AJ. Identifying risk for attrition during treatment for depression. Psychotherapy and Psychosomatics. 2009;78(6):372-9. PMID:19738403. PMCID:PMC2820313.

Cook IA, Balasubramani GK, Eng H, Friedman E, Young EA, Martin J, Nay WT, Ritz L, Rush AJ, Stegman D, Warden D, Trivedi MH, Wisniewski SR. Electronic source materials in clinical research: acceptability and validity of symptom self-rating in major depressive disorder. Journal of Psychiatric Research. 2007 Nov;41(9):737-43. PMID:17275840.

Fabio A, Loeber R, Balasubramani GK, Roth J, Fu W, Farrington DP. Why some generations are more violent than others: assessment of age, period, and cohort effects. American Journal of Epidemiology. 2006 Jul 15;164(2):151-60. PMID:16775045.

Wisniewski SR, Rush AJ, Balasubramani GK, Trivedi MH, Nierenberg AA, STARD Investigators. Self-rated global measure of the frequency, intensity, and burden of side effects. Journal of Psychiatric Practice. 2006 Mar;12(2):71-9. PMID:16728903.

Balasubramani GK, Wisniewski SR, Zhang H, Eng HF. Development of an efficient SAS macro to perform permutation tests for two independent samples. Computer Methods and Programs in Biomedicine. 2005 Aug;79(2):179-87. PMID:15904990.

Suresh Chandra K, Sampath K, Balasubramani GK. Markov Sampling for finite poulation. Biometrika. 1992;29(1):210-213.

Balasubramani  K Goundappa
© 2017 by University of Pittsburgh Graduate School of Public Health

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