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EOH Journal Club Seminar - Fall 2018

Thursday 9/13 11:00AM - 12:00PM
4140 Public Health, Young Seminar Room
EOH Journal Club Seminar - Fall 2018
Date: Thursday September 13, 2018
Time: 11am - 12pm
Presenter: Cody Wolfe

Paper: High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

Authors: Dunja Mrdjen, Anto Pavlovic, Felix J. Hartmann, Doron Merkler, Melanie Greter, Burkhard Becher

Abstract: Individual reports suggest that the central nervous system (CNS) contains multiple immune cell types with diverse roles in tissue homeostasis, immune defense, and neurological diseases. It has been challenging to map leukocytes across the entire brain, and in particular in pathology, where phenotypic changes and influx of blood-derived cells prevent a clear distinction between reactive leukocyte populations. Here, we applied high-dimensional single-cell mass and fluorescence cytometry, in parallel with genetic fate mapping systems, to identify, locate, and characterize multiple distinct immune populations within the mammalian CNS. Using this approach, we revealed that microglia, several subsets of border-associated macrophages and dendritic cells coexist in the CNS at steady state and exhibit disease-specific transformations in the immune microenvironment during aging and in models of Alzheimer’s disease and multiple sclerosis. Together, these data and the described framework provide a resource for the study of disease mechanisms, potential biomarkers, and therapeutic targets in CNS disease.

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Last Updated On Monday, September 10, 2018 by Orbell, Adam W
Created On Friday, September 07, 2018

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