Intrinsic to this research mission is that fundamental information regarding actions of environmental toxicants will provide insight into basic human biology in health and disease.
Accordingly, current research includes:
- fundamental studies on free radical biology and especially oxidative lipidomics and mitochondrial function
- genetic basis of susceptibility to injurious agents including gene X environment approaches
- cellular and molecular regulation of reparative response to injury including mesenchymal stem cells as modifying biological therapeutic agents
- cardiopulmonary toxicology of heavy metals and particulate matter including nanoparticles
- molecular carcinogenesis including metabolism of telomeres and DNA damage and repair
- genetic and epigenetic contributions to neurodegenerative disease with focus on cholesterol dyshomeostasis
- integrated studies in complex disorders such as environmental induced interstitial pulmonary fibrosis.
In addition, a focus on exposure science and environmental epidemiology supports efforts into the health effects of air pollution and public health concerns associated with energy procurement including unconventional natural gas development. Translation of these collective efforts in basic and applied research is in part provided by members of EOH active in environmental policy, risk assessment, and community behavioral sciences. These efforts coincide and are coordinated with mentoring and educational programs for pre-doctoral (PhD, MS) and (MPH) students.